Drug interactions
Acetylsalicylic acid + Methotrexate
Severity: Major
Acetylsalicylic acid and Methotrexate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates can raise methotrexate concentrations and increase the risk of bone marrow suppression, mucositis, and hepatic and renal toxicity.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Acetylsalicylic acid and Methotrexate interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Free 14-day trial. No card needed.
Other interactions of Acetylsalicylic acid
Other interactions of Methotrexate
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
