Drug interactions
Acyclovir + Tobramycin
Severity: Moderate
Acyclovir and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the kidney, and intravenous acyclovir may cause crystal nephropathy, so combining it with tobramycin raises the risk of acute kidney injury.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Acyclovir and Tobramycin interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Free 14-day trial. No card needed.
Other interactions of Tobramycin
Other interactions of Acyclovir
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.