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Drug interactions

Alogliptin-metformin + Clozapine

Severity: Major

Alogliptin-metformin and Clozapine: major interaction.

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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Clozapine is strongly associated with hyperglycemia, new-onset diabetes and rarely ketoacidosis, so it can markedly worsen glycemic control.

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