Drug interactions
amikacin + magnesium citrate
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Amikacin can cause renal magnesium wasting and hypomagnesemia. Occasional magnesium citrate is little affected, though low magnesium is relevant to aminoglycoside patients.
Mechanism of action
Aminoglycoside tubular toxicity increases urinary magnesium excretion.
Clinical management
Monitor serum magnesium and renal function during amikacin therapy and replace magnesium if low.
Drug reference
Frequently asked questions
Can I take amikacin with magnesium citrate?
The interaction is rated: Minor. Amikacin can cause renal magnesium wasting and hypomagnesemia. Occasional magnesium citrate is little affected, though low magnesium is relevant to aminoglycoside patients.
How serious is the interaction between amikacin and magnesium citrate?
The interaction is rated: Minor. Evidence level: Low.
How is the interaction between amikacin and magnesium citrate managed?
Monitor serum magnesium and renal function during amikacin therapy and replace magnesium if low.
Why do amikacin and magnesium citrate interact?
Aminoglycoside tubular toxicity increases urinary magnesium excretion.
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