Drug interactions
apixaban + ketoconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
↑ apixaban → bleeding risk.
Mechanism of action
Strong CYP3A4/P-gp inhibition.
Clinical management
Avoid or reduce dose per label; monitor bleeding.
Drug reference
References
Frequently asked questions
Can I take apixaban with ketoconazole?
The interaction is rated: Major. ↑ apixaban → bleeding risk.
How serious is the interaction between apixaban and ketoconazole?
The interaction is rated: Major. Evidence level: High.
How is the interaction between apixaban and ketoconazole managed?
Avoid or reduce dose per label; monitor bleeding.
Why do apixaban and ketoconazole interact?
Strong CYP3A4/P-gp inhibition.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.