Drug reference
ketoconazole
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Anti Fungals (Azoles)
Mechanism of action
Inhibits cytochrome P450-dependent synthesis of ergosterol, which in turn inhibits cell-membrane formation
Common side effects
- Stinging
- Pruritus
- Irritation, severe
- Hair loss/alopecia
- Abnormal hair texture
Contraindications
- Contraindicated with dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, and ranolazine; can cause elevated plasma concentrations of these drugs and may prolong QT intervals, sometimes resulting in life-threatening ventricular dysrhythmias (eg, torsades de pointes)…
Known interactions (32)
- alfuzosin + ketoconazole Contraindicated
- alprazolam + ketoconazole Contraindicated
- avanafil + ketoconazole Contraindicated
- conivaptan + ketoconazole Contraindicated
- dofetilide + ketoconazole Contraindicated
- dronedarone + ketoconazole Contraindicated
- eletriptan + ketoconazole Contraindicated
- eplerenone + ketoconazole Contraindicated
- ergotamine + ketoconazole Contraindicated
- flibanserin + ketoconazole Contraindicated
- ivabradine + ketoconazole Contraindicated
- ketoconazole + lomitapide Contraindicated
- ketoconazole + lurasidone Contraindicated
- ketoconazole + pimozide Contraindicated
- ketoconazole + ranolazine Contraindicated
- ketoconazole + rivaroxaban Contraindicated
- ketoconazole + terfenadine Contraindicated
- ketoconazole + ticagrelor Contraindicated
- apixaban + ketoconazole Major
- colchicine + ketoconazole Major
- dabigatran + ketoconazole Major
- everolimus + ketoconazole Major
- fluconazole + ketoconazole Major
- ketoconazole + macitentan Major
- ketoconazole + oxycodone Major
- ketoconazole + pantoprazole Major
- ketoconazole + quetiapine Major
- ketoconazole + rifampin Major
- ketoconazole + warfarin Major
- famotidine + ketoconazole Moderate
- indapamide + ketoconazole Moderate
- isoniazid + ketoconazole Moderate
Related conditions
Frequently asked questions
What drug class is ketoconazole?
ketoconazole belongs to: Anti Fungals.
How does ketoconazole work?
Inhibits cytochrome P450-dependent synthesis of ergosterol, which in turn inhibits cell-membrane formation
What are the common side effects of ketoconazole?
Stinging, Pruritus, Irritation, severe, Hair loss/alopecia, Abnormal hair texture
Which drugs interact with ketoconazole?
alfuzosin, alprazolam, avanafil, conivaptan, dofetilide, dronedarone, eletriptan, eplerenone, ergotamine, flibanserin, ivabradine, lomitapide, lurasidone, pimozide, ranolazine
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