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Pregătire NAPLEX

NAPLEX Pharmacotherapy Foundations

Top 200 drugs and key interactions. Original NAPLEX-style single-best-answer questions on the most commonly dispensed drugs: mechanism, indications, adverse effects, interactions, dosing, counselling, special populations and pharmacy calculations. Every question has a concise explanation and public references (FDA labels via DailyMed, NCBI Bookshelf, FDA). Aligned to the NABP NAPLEX Content Outline domains (Foundational Knowledge, Medication Use Process, Person-Centered Assessment and Treatment Planning). Educational use only; not an official NABP product.

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Ce include

  • Interacțiuni medicamentoase (27)
  • Reacții adverse (24)
  • Mecanism de acțiune (22)
  • Indicații (20)
  • Calcule farmaceutice (15)
  • Consiliere (15)
  • Dozare (14)
  • Grupe speciale de pacienți (13)

150 de întrebări

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1 / 5 · Mecanism de acțiune

Apixaban prevents stroke in non-valvular atrial fibrillation by which mechanism?

  1. Inhibition of vitamin K epoxide reductase
  2. Inhibition of glycoprotein IIb/IIIa
  3. Direct inhibition of thrombin (factor IIa)
  4. Direct, selective inhibition of free and clot-bound factor Xa
  5. Binding antithrombin to accelerate factor Xa inactivation
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Răspuns corect: D. Direct, selective inhibition of free and clot-bound factor Xa

Apixaban, rivaroxaban and edoxaban are direct factor Xa inhibitors that do not require antithrombin. Dabigatran is the oral direct thrombin inhibitor, and heparins act through antithrombin.

2 / 5 · Interacțiuni medicamentoase

A patient who takes atorvastatin drinks large amounts of grapefruit juice. What is the pharmacist's best advice?

  1. Limit grapefruit juice because intestinal CYP3A4 inhibition can raise atorvastatin levels
  2. Grapefruit juice lowers atorvastatin efficacy, so take double the dose
  3. Grapefruit juice only matters with penicillins
  4. Grapefruit has no interactions with any drug
  5. Take the statin only in the morning to avoid the effect
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Răspuns corect: A. Limit grapefruit juice because intestinal CYP3A4 inhibition can raise atorvastatin levels

Grapefruit juice irreversibly inhibits intestinal CYP3A4; the effect is greater for simvastatin and lovastatin than atorvastatin, but large quantities (over 1.2 L per day) may raise exposure. Pravastatin and rosuvastatin are unaffected.

3 / 5 · Calcule farmaceutice

You need 50 mL of a 2% solution and have a 10% stock solution. How many mL of stock are required?

  1. 10 mL
  2. 25 mL
  3. 5 mL
  4. 20 mL
  5. 2 mL
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Răspuns corect: A. 10 mL

C1V1 = C2V2: 10% x V1 = 2% x 50 mL, so V1 = 100 / 10 = 10 mL; add 40 mL of diluent.

4 / 5 · Reacții adverse

A patient on simvastatin reports new diffuse muscle pain and dark urine. What is the most appropriate action?

  1. Add ezetimibe and continue
  2. Stop the statin and obtain creatine kinase and renal function urgently
  3. Take the statin at night only
  4. Continue and recheck in 6 months
  5. Double the dose
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Răspuns corect: B. Stop the statin and obtain creatine kinase and renal function urgently

Statin-associated rhabdomyolysis presents with myalgia, weakness and myoglobinuria and can cause acute kidney injury. Risk factors include high dose, interacting drugs, hypothyroidism, renal disease and older age.

5 / 5 · Dozare

What INR range is typical for a patient on warfarin for non-valvular AF or VTE?

  1. 1.0 to 1.5
  2. 4.0 to 5.0
  3. 2.0 to 3.0
  4. 3.5 to 4.5
  5. 0.8 to 1.2
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Răspuns corect: C. 2.0 to 3.0

A target INR of 2.5 (range 2-3) applies to most indications; mechanical mitral valves generally target 3 (2.5-3.5). Time in therapeutic range correlates with outcomes.

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