Drug interactions
5-htp + Duloxetine
Severity: Major
5-htp and Duloxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
5-HTP is a serotonin precursor, and giving it with duloxetine can increase serotonin activity enough to cause serotonin syndrome.
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