Drug reference
duloxetine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (SNRIs)
Mechanism of action
Exact mechanism of action unknown; inhibits reuptake of serotonin and norepinephrine; weakly inhibits reuptake of dopamine; has no MAOI activity; has no significant activity for histaminergic H1 receptor or alpha2-adrenergic receptor
Common side effects
- Dry mouth
- Constipation
- Dizziness
- Somnolence
- Headache
- Fatigue
- Nausea
Known interactions (11)
- duloxetine + isocarboxazid Contraindicated
- duloxetine + linezolid Contraindicated
- duloxetine + phenelzine Contraindicated
- duloxetine + procarbazine Contraindicated
- duloxetine + safinamide Contraindicated
- duloxetine + selegiline Contraindicated
- duloxetine + thioridazine Contraindicated
- duloxetine + tranylcypromine Contraindicated
- dextromethorphan + duloxetine Major
- duloxetine + paroxetine Major
- duloxetine + mexiletine Moderate
Related conditions
Frequently asked questions
What drug class is duloxetine?
duloxetine belongs to: Central Nervous System.
How does duloxetine work?
Exact mechanism of action unknown; inhibits reuptake of serotonin and norepinephrine; weakly inhibits reuptake of dopamine; has no MAOI activity; has no significant activity for histaminergic H1 receptor or alpha2-adrenergic receptor
What are the common side effects of duloxetine?
Dry mouth, Constipation, Dizziness, Somnolence, Headache, Fatigue, Nausea
Which drugs interact with duloxetine?
isocarboxazid, linezolid, phenelzine, procarbazine, safinamide, selegiline, thioridazine, tranylcypromine, dextromethorphan, paroxetine, mexiletine
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