Drug interactions
Acalabrutinib + Methotrexate
Severity: Moderate
Acalabrutinib and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acalabrutinib may increase methotrexate exposure by inhibiting intestinal BCRP, and both agents can lower blood counts.
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Other interactions of Methotrexate
Other interactions of Acalabrutinib
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