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Drug interactions

Acetazolamide + Aspirin rectal

Severity: Major

Acetazolamide and Aspirin rectal: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Acetazolamide can raise salicylate concentrations in the central nervous system and reduce salicylate renal clearance, particularly with high-dose aspirin, producing salicylate toxicity such as tinnitus, confusion and metabolic acidosis.

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