Drug interactions
Acetazolamide + Salsalate
Severity: Major
Acetazolamide and Salsalate: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolysed to salicylic acid, so acetazolamide can increase salicylate penetration into the CNS and reduce renal clearance, causing toxicity with tinnitus, confusion and acidosis.
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Other interactions of Acetazolamide
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