Drug interactions
Adagrasib + Sirolimus
Severity: Major
Adagrasib and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adagrasib inhibits CYP3A4 and P-glycoprotein, both of which govern sirolimus disposition.
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to see why Adagrasib and Sirolimus interact, what to do about it, and the sources.
- Mechanism of action
- Clinical management
- Evidence level
Free 14-day trial. No card needed.
Other interactions of Sirolimus
Other interactions of Adagrasib
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
