Drug reference
sirolimus
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Miscellaneous (Immunosuppressants)
Mechanism of action
Inhibits T-cell activation and proliferation and inhibits antibody production that occurs in response to antigenic and cytokine stimulation; inhibits T- cell proliferation by inhibiting progression from the G1 to the S phase of the cell cycle
Common side effects
- Rash
- Arthralgia
- Constipation
- Thrombocytopenia
- Hypertriglyceridemia
- Hypercholesterolemia
- Peripheral edema
Known interactions (8)
- efavirenz + sirolimus Major
- fluconazole + sirolimus Major
- griseofulvin + sirolimus Major
- isavuconazole + sirolimus Major
- sirolimus + voriconazole Major
- aprepitant + sirolimus Moderate
- dasatinib + sirolimus Moderate
- hepatitis a vaccine inactivated + sirolimus Moderate
Related conditions
Frequently asked questions
What drug class is sirolimus?
sirolimus belongs to: Miscellaneous.
How does sirolimus work?
Inhibits T-cell activation and proliferation and inhibits antibody production that occurs in response to antigenic and cytokine stimulation; inhibits T- cell proliferation by inhibiting progression from the G1 to the S phase of the cell cycle
What are the common side effects of sirolimus?
Rash, Arthralgia, Constipation, Thrombocytopenia, Hypertriglyceridemia, Hypercholesterolemia, Peripheral edema
Which drugs interact with sirolimus?
efavirenz, fluconazole, griseofulvin, isavuconazole, voriconazole, aprepitant, dasatinib, hepatitis a vaccine inactivated
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