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Drug interactions

Adrenaline-articaine + Phentolamine

Severity: Moderate

Adrenaline-articaine and Phentolamine: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Phentolamine blocks alpha receptors, so epinephrine's beta-mediated vasodilation is unopposed and can cause marked hypotension with reflex tachycardia.

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