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Drug interactions

Alfentanil + Fluoxetine

Severity: Major

Alfentanil and Fluoxetine: major interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Fluoxetine with an opioid such as alfentanil can cause serotonin syndrome, with agitation, hyperthermia, clonus and autonomic instability.

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