Drug interactions
Acetylsalicylic acid + Captopril
Severity: Moderate
Acetylsalicylic acid and Captopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aspirin at analgesic or anti-inflammatory doses can blunt the blood pressure lowering effect of captopril and may reduce kidney function, particularly in patients who are volume depleted, elderly or have existing renal impairment. Low-dose aspirin for cardiovascular protection carries a much smaller risk.
What this interaction means in plain words
Acetylsalicylic acid and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Captopril belongs to Cardiovascular.
Why it happens
Inhibition of cyclooxygenase reduces vasodilatory renal prostaglandins, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Prefer low-dose aspirin when it is needed for cardiovascular protection and avoid regular higher doses. Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Acetylsalicylic acid with Captopril?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Captopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aspirin at analgesic or anti-inflammatory doses can blunt the blood pressure lowering effect of captopril and may reduce kidney function, particularly in patients who are volume depleted, elderly or have existing renal impairment. Low-dose aspirin for cardiovascular protection carries a much smaller risk.
How serious is the interaction between Acetylsalicylic acid and Captopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer low-dose aspirin when it is needed for cardiovascular protection and avoid regular higher doses. Monitor blood pressure, serum creatinine and potassium, and keep the patient well hydrated.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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