Drug interactions
Acetylsalicylic acid + Dichlorphenamide
Severity: Major
Acetylsalicylic acid and Dichlorphenamide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide inhibits carbonic anhydrase and aspirin (particularly at analgesic doses) adds to metabolic acidosis. Salicylate levels may also rise.
What this interaction means in plain words
Acetylsalicylic acid and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Acetylsalicylic acid belongs to Musculoskeletal; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Carbonic anhydrase inhibition reduces salicylate excretion and worsens acidosis
What to do
Avoid high-dose aspirin; if low-dose aspirin is needed, monitor acid-base status and salicylate effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Acetylsalicylic acid with Dichlorphenamide?
MediHelp rates the interaction as major. Acetylsalicylic acid and Dichlorphenamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dichlorphenamide inhibits carbonic anhydrase and aspirin (particularly at analgesic doses) adds to metabolic acidosis. Salicylate levels may also rise.
How serious is the interaction between Acetylsalicylic acid and Dichlorphenamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high-dose aspirin; if low-dose aspirin is needed, monitor acid-base status and salicylate effects.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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