Drug interactions
Acetylsalicylic acid + Diltiazem
Severity: Minor
Acetylsalicylic acid and Diltiazem: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium channel blockers such as diltiazem have mild antiplatelet effects and may add to the antiplatelet action of aspirin. This may slightly increase bleeding tendency, though clinical significance is usually small.
What this interaction means in plain words
Acetylsalicylic acid and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Diltiazem belongs to Cardiovascular.
Why it happens
Additive inhibition of platelet function through reduced platelet calcium influx plus cyclooxygenase inhibition.
What to do
No dose change is required. Be alert for bruising or bleeding, especially if other antithrombotics are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Frequently asked questions
Can I take Acetylsalicylic acid with Diltiazem?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Diltiazem have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium channel blockers such as diltiazem have mild antiplatelet effects and may add to the antiplatelet action of aspirin. This may slightly increase bleeding tendency, though clinical significance is usually small.
How serious is the interaction between Acetylsalicylic acid and Diltiazem?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required. Be alert for bruising or bleeding, especially if other antithrombotics are also used.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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