Drug interactions
Acetylsalicylic acid + Doxazosin
Severity: Minor
Acetylsalicylic acid and Doxazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAID-dose aspirin may reduce the antihypertensive effect of doxazosin through sodium and fluid retention. Low-dose aspirin is unlikely to have a significant effect.
What this interaction means in plain words
Acetylsalicylic acid and Doxazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Doxazosin belongs to Genitourinary.
Why it happens
Inhibition of vasodilatory prostaglandins and sodium retention counteract alpha-blocker vasodilation.
What to do
Monitor blood pressure if regular high-dose aspirin is started or stopped; low-dose aspirin needs no change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Doxazosin
- Alfuzosin + Doxazosin Major
- Amifostine + Doxazosin Major
- Avanafil + Doxazosin Major
- Doxazosin + Dutasteride-tamsulosin Major
- Doxazosin + Phentolamine Major
- Doxazosin + Prazosin Major
Frequently asked questions
Can I take Acetylsalicylic acid with Doxazosin?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Doxazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAID-dose aspirin may reduce the antihypertensive effect of doxazosin through sodium and fluid retention. Low-dose aspirin is unlikely to have a significant effect.
How serious is the interaction between Acetylsalicylic acid and Doxazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if regular high-dose aspirin is started or stopped; low-dose aspirin needs no change.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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