Drug interactions
Acetylsalicylic acid + Escitalopram
Severity: Moderate
Acetylsalicylic acid and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Escitalopram with aspirin raises the risk of bleeding, especially in the upper gastrointestinal tract. Risk is greater in older patients and those with prior GI bleeding.
What this interaction means in plain words
Acetylsalicylic acid and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Escitalopram belongs to Central Nervous System.
Why it happens
SSRI-induced depletion of platelet serotonin impairs aggregation, additive to aspirin's antiplatelet and mucosal effects.
What to do
Consider a proton pump inhibitor in patients with GI risk factors and counsel on signs of bleeding. Reassess the need for aspirin in patients without a clear cardiovascular indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Acetylsalicylic acid with Escitalopram?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Escitalopram with aspirin raises the risk of bleeding, especially in the upper gastrointestinal tract. Risk is greater in older patients and those with prior GI bleeding.
How serious is the interaction between Acetylsalicylic acid and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in patients with GI risk factors and counsel on signs of bleeding. Reassess the need for aspirin in patients without a clear cardiovascular indication.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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