Drug interactions
Acetylsalicylic acid + Indapamide
Severity: Minor
Acetylsalicylic acid and Indapamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High-dose aspirin may blunt the antihypertensive and diuretic effect of indapamide and may impair renal function in volume-depleted patients. Low-dose aspirin has little effect.
What this interaction means in plain words
Acetylsalicylic acid and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Acetylsalicylic acid belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
Prostaglandin inhibition reduces renal perfusion and sodium excretion.
What to do
Monitor blood pressure and renal function when regular analgesic-dose aspirin is used with indapamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Indapamide
Frequently asked questions
Can I take Acetylsalicylic acid with Indapamide?
MediHelp rates the interaction as minor. Acetylsalicylic acid and Indapamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High-dose aspirin may blunt the antihypertensive and diuretic effect of indapamide and may impair renal function in volume-depleted patients. Low-dose aspirin has little effect.
How serious is the interaction between Acetylsalicylic acid and Indapamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function when regular analgesic-dose aspirin is used with indapamide.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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