Drug interactions
Acetylsalicylic acid + Insulin lispro
Severity: Moderate
Acetylsalicylic acid and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High doses of salicylates can lower blood glucose and may enhance the effect of insulin, leading to hypoglycemia. Low-dose aspirin is unlikely to matter.
What this interaction means in plain words
Acetylsalicylic acid and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Insulin lispro belongs to Endocrine.
Why it happens
High-dose salicylates have intrinsic glucose-lowering effects, adding to insulin's action.
What to do
With high-dose salicylate therapy, monitor blood glucose more often and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Insulin lispro
Frequently asked questions
Can I take Acetylsalicylic acid with Insulin lispro?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. High doses of salicylates can lower blood glucose and may enhance the effect of insulin, leading to hypoglycemia. Low-dose aspirin is unlikely to matter.
How serious is the interaction between Acetylsalicylic acid and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With high-dose salicylate therapy, monitor blood glucose more often and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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