Drug interactions
Acetylsalicylic acid + Olmesartan
Severity: Moderate
Acetylsalicylic acid and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-inflammatory doses of aspirin can reduce olmesartan's antihypertensive effect and may worsen renal function, particularly in elderly or volume-depleted patients. Low-dose aspirin carries little risk.
What this interaction means in plain words
Acetylsalicylic acid and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Olmesartan belongs to Cardiovascular.
Why it happens
Aspirin inhibits renal vasodilatory prostaglandins, lowering renal perfusion and opposing ARB effect, while ARB reduces glomerular filtration pressure.
What to do
Monitor blood pressure, creatinine and potassium with higher-dose aspirin; maintain hydration and prefer low-dose aspirin or another analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Acetylsalicylic acid and Olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac intranasal Contraindicated
- Abciximab + Acetylsalicylic acid Major
- Acemetacin + Acetylsalicylic acid Major
- Acetazolamide + Acetylsalicylic acid Major
- Acetylsalicylic acid + Alteplase Major
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Acetylsalicylic acid with Olmesartan?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-inflammatory doses of aspirin can reduce olmesartan's antihypertensive effect and may worsen renal function, particularly in elderly or volume-depleted patients. Low-dose aspirin carries little risk.
How serious is the interaction between Acetylsalicylic acid and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium with higher-dose aspirin; maintain hydration and prefer low-dose aspirin or another analgesic.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
