Référentiel des médicaments
Atrasentan
Atrasentan is a medicine in the class miscellaneous. It is used for nephropathy.
- Classe médicamenteuse: Miscellaneous
- Indications: nephropathy
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Formes courantes
- comprimé
- Dosages courants
- 0.75 mg
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Atrasentan is an endothelin type A (ET A) receptor antagonist with >1800-fold selectivity for ET A over the endothelin type B receptor. Endothelin-1 is thought to contribute to IgAN pathogenesis via the ET A receptor.
Posologie adulte habituelle (résumé de la notice)
Reduction of proteinuria in primary IgAN: 0.75 mg orally once daily with or without food.
Grossesse et allaitement
- Grossesse
- Unsafe Contraindicated; animal studies show teratogenicity and fetal harm including birth defects and fetal death.
- Allaitement
- Unsafe No human milk data; advise not to breastfeed during treatment because of potential adverse reactions such as fluid retention in infants.
Effets indésirables signalés
- Peripheral edema
- Anemia
- Liver transaminase elevation
Mises en garde encadrées
- Embryo-fetal toxicity: contraindicated in pregnancy; may cause major birth defects based on animal data. Exclude pregnancy before starting. Use effective contraception before, during, and for two weeks after treatment. Stop as soon as possible if pregnancy occurs.
Contre-indications
- Pregnancy.
- History of hypersensitivity reaction to atrasentan or any component of the product.
Précautions particulières
- Embryo-fetal toxicity: may cause fetal harm; exclude pregnancy before starting and use effective contraception.
- Hepatotoxicity: obtain liver enzymes before starting and as clinically indicated; do not initiate in severe hepatic impairment; discontinue if clinically relevant aminotransferase elevations occur.
- Fluid retention: not evaluated in IgAN patients with heart failure; if significant, consider diuretic and interrupting treatment.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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Questions fréquentes
What is Atrasentan used for?
Atrasentan is a medicine in the class miscellaneous. It is used for Nephropathy.
What side effects have been reported with Atrasentan?
Peripheral edema, Anemia, Liver transaminase elevation. Serious warning: Embryo-fetal toxicity: contraindicated in pregnancy; may cause major birth defects based on animal data.
Can Atrasentan be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Contraindicated; animal studies show teratogenicity and fetal harm including birth defects and fetal death. Breastfeeding: Unsafe. No human milk data; advise not to breastfeed during treatment because of potential adverse reactions such as fluid retention in infants.
What does Atrasentan interact with?
MediHelp does not list a checked interaction for Atrasentan yet. Always tell your pharmacist about every medicine you take.
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