Référentiel des médicaments
Burosumab
Burosumab is a medicine in the class miscellaneous. It is used for hypophosphatemia.
- Classe médicamenteuse: Miscellaneous
- Indications: hypophosphatemia
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- M05BX05
- Formes courantes
- injection
- Dosages courants
- 10 mg/ml
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Burosumab-twza binds to and inhibits the biological activity of FGF23, restoring renal phosphate reabsorption and increasing serum 1,25 dihydroxy vitamin D.
Posologie adulte habituelle (résumé de la notice)
Adult XLH: starting 1 mg/kg rounded to nearest 10 mg, maximum 90 mg, subcutaneously every four weeks; may increase to 0.5 mg/kg (max 90 mg) every 2 weeks, then 1 mg/kg (max 90 mg) every 2 weeks if needed.
Grossesse et allaitement
- Grossesse
- Unknown No human data. In monkeys there were no birth defects, but fetal loss and preterm birth at high exposure with high maternal phosphate. Monitor serum phosphate throughout pregnancy.
- Allaitement
- Unknown No data on milk levels or infant effects. As a large antibody, infant absorption is likely low. Weigh breastfeeding benefits against the mother's need.
Effets indésirables signalés
- Pyrexia
- Injection site reaction
- Cough
- Vomiting
- Headache
- Tooth abscess
Contre-indications
- Concomitant use with oral phosphate and/or active vitamin D analogs, due to risk of hyperphosphatemia.
- When serum phosphorus is within or above the normal range for age.
- Severe renal impairment or end stage renal disease.
Précautions particulières
- Hypersensitivity reactions (rash, urticaria) reported; discontinue if serious.
- Hyperphosphatemia may increase nephrocalcinosis risk; dose interruption or reduction may be required.
- Hypercalcemia: monitor calcium and PTH in high-risk patients; do not administer in moderate to severe hypercalcemia until managed.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Renal and hepatic dose adjustments
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- Dosing in older adults
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Questions fréquentes
What is Burosumab used for?
Burosumab is a medicine in the class miscellaneous. It is used for Hypophosphatemia.
What side effects have been reported with Burosumab?
Pyrexia, Injection site reaction, Cough, Vomiting, Headache, Tooth abscess.
Can Burosumab be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human data. In monkeys there were no birth defects, but fetal loss and preterm birth at high exposure with high maternal phosphate. Monitor serum phosphate throughout pregnancy. Breastfeeding: Unknown. No data on milk levels or infant effects. As a large antibody, infant absorption is likely low. Weigh breastfeeding benefits against the mother's need.
What does Burosumab interact with?
MediHelp does not list a checked interaction for Burosumab yet. Always tell your pharmacist about every medicine you take.
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