Référentiel des médicaments
Collagenase
Collagenase is a medicine in the class miscellaneous. It is used for burns.
- Classe médicamenteuse: Miscellaneous
- Indications: burns
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Interactions connues
- 1 (Modérée: 1)
Indications
Mécanisme d'action
Collagenase digests collagen in the physiological pH and temperature range, removing detritus and contributing to granulation tissue formation and epithelization. Collagen in healthy tissue or new granulation tissue is not attacked.
Posologie adulte habituelle (résumé de la notice)
Debridement of chronic dermal ulcers and severely burned areas: apply topically to the wound once daily, or more often if the dressing becomes soiled; stop when debridement is complete and granulation tissue is well established
Grossesse et allaitement
- Grossesse
- Unknown Injection (Xiaflex): blood levels are undetectable after injection; animal studies showed no harm; human case data are insufficient. Ointment (Santyl): not meaningfully absorbed. Use if needed; some labels advise postponing Xiaflex until after pregnancy.
- Allaitement
- Safe No milk data. Blood levels are undetectable after Xiaflex injection and the ointment is not meaningfully absorbed, so infant exposure is unlikely. US label: weigh benefits. Do not apply ointment to the breast.
Effets indésirables signalés
- Transient erythema of surrounding tissue
- Systemic hypersensitivity (one case reported)
Contre-indications
- Local or systemic hypersensitivity to collagenase
Précautions particulières
- Enzyme activity is best at pH 6 to 8; higher or lower pH reduces activity.
- Detergents and heavy metal ions (mercury, silver) in some antiseptics reduce activity. Cleanse the site with repeated normal saline washings first. Avoid soaks containing metal ions or acidic solutions.
- Monitor debilitated patients closely for systemic bacterial infection, as debriding enzymes may theoretically increase the risk of bacteremia.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (1)
- Collagenase + Silver sulfadiazine Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
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Questions fréquentes
What is Collagenase used for?
Collagenase is a medicine in the class miscellaneous. It is used for Burns, Skin ulcers.
What side effects have been reported with Collagenase?
Transient erythema of surrounding tissue, Systemic hypersensitivity (one case reported).
Can Collagenase be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Injection (Xiaflex): blood levels are undetectable after injection; animal studies showed no harm; human case data are insufficient. Ointment (Santyl): not meaningfully absorbed. Use if needed; some labels advise postponing Xiaflex until after pregnancy. Breastfeeding: Safe. No milk data. Blood levels are undetectable after Xiaflex injection and the ointment is not meaningfully absorbed, so infant exposure is unlikely. US label: weigh benefits. Do not apply ointment to the breast.
What does Collagenase interact with?
MediHelp lists 1 known interactions for Collagenase. Moderate: 1. The most serious include Silver sulfadiazine.
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