Référentiel des médicaments
Daridorexant
Daridorexant is a medicine in the class central nervous system. It is used for insomnia.
- Classe médicamenteuse: Central Nervous System
- Indications: insomnia
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Code ATC
- N05CJ03
- Formes courantes
- comprimé
- Interactions connues
- 173 (Majeure: 12 · Modérée: 146 · Mineure: 15)
- Noms commerciaux
- 2
- Pays et marchés
- 2
Indications
Mécanisme d'action
Presumed to act through antagonism of orexin receptors; blocking binding of orexin A and orexin B to OX1R and OX2R is thought to suppress wake drive.
Posologie adulte habituelle (résumé de la notice)
Insomnia (sleep onset and/or maintenance): 25 mg to 50 mg orally once per night, within 30 minutes of going to bed, with at least 7 hours remaining before planned awakening.
Grossesse et allaitement
- Grossesse
- Unknown No human pregnancy data. In rats and rabbits, doses up to 8-10 times human exposure caused no fetal toxicity or malformations. A US pregnancy registry exists. Prefer non-drug measures for insomnia in pregnancy; use only if clearly needed.
- Allaitement
- Safe Passes into milk in very low amounts (well under 1% of the mother's weight-adjusted dose). LactMed: not a reason to stop breastfeeding. US label: watch the infant for excessive sedation; also check feeding and weight gain.
Effets indésirables signalés
- Headache
- Somnolence or fatigue
- Dizziness
- Nausea
- Nightmares or abnormal dreams (post-marketing)
- Hypersensitivity including angioedema, rash, urticaria (post-marketing)
Contre-indications
- Narcolepsy.
- History of hypersensitivity to daridorexant or any component of the product; angioedema with pharyngeal involvement has been reported.
Précautions particulières
- CNS depressant effects and daytime impairment, which may persist for several days; caution against next-day driving; risk increases with less than a full night of sleep remaining, higher doses, or other CNS depressants; falls risk especially in the elderly.
- Worsening of depression and suicidal ideation; use with caution in patients with depressive symptoms and monitor suicide risk.
- Sleep paralysis, hypnagogic/hypnopompic hallucinations and cataplexy-like symptoms may occur.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (173)
- Amobarbital + Daridorexant Major
- Apalutamide + Daridorexant Major
- Clarithromycin + Daridorexant Major
- Daridorexant + Enzalutamide Major
- Daridorexant + Fluvoxamine Major
- Daridorexant + Itraconazole Major
- Daridorexant + Ketoconazole Major
- Daridorexant + Mifepristone Major
- Daridorexant + Phenytoin Major
- Daridorexant + Posaconazole Major
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- Renal and hepatic dose adjustments
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Questions fréquentes
What is Daridorexant used for?
Daridorexant is a medicine in the class central nervous system. It is used for Insomnia.
What side effects have been reported with Daridorexant?
Headache, Somnolence or fatigue, Dizziness, Nausea, Nightmares or abnormal dreams (post-marketing), Hypersensitivity including angioedema, rash, urticaria (post-marketing).
Can Daridorexant be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. No human pregnancy data. In rats and rabbits, doses up to 8-10 times human exposure caused no fetal toxicity or malformations. A US pregnancy registry exists. Prefer non-drug measures for insomnia in pregnancy; use only if clearly needed. Breastfeeding: Safe. Passes into milk in very low amounts (well under 1% of the mother's weight-adjusted dose). LactMed: not a reason to stop breastfeeding. US label: watch the infant for excessive sedation; also check feeding and weight gain.
What does Daridorexant interact with?
MediHelp lists 173 known interactions for Daridorexant. Major: 12 · Moderate: 146 · Minor: 15. The most serious include Amobarbital, Apalutamide, Clarithromycin.
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