Référentiel des médicaments
Hydroxocobalamin
Hydroxocobalamin is a medicine in the class miscellaneous. It is used for b12 deficiency.
- Classe médicamenteuse: Miscellaneous
- Indications: b12 deficiency
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- V03AB33
- Formes courantes
- injection
- Dosages courants
- 1 mg/ml, 1000 mcg, 1000 mcg/ml
- Noms commerciaux
- 19
- Pays et marchés
- 5
Indications
Mécanisme d'action
Vitamin B12 with hydroxyl group complexed to cobalt which can be displaced by cyanide resulting in cyanocobalamin that is renally excreted
Posologie adulte habituelle (résumé de la notice)
Cyanide Poisoning: 70 mg/kg (usually 5 g) IV infusion over 15 minutes; additional 5 g IV may be given depending on severity of poisoning and clinical response
Grossesse et allaitement
- Grossesse
- Unknown Vitamin B12 injections for deficiency are safe and needed in pregnancy. Cyanokit (5 g IV antidote for cyanide poisoning): human data insufficient; animal studies showed skeletal and soft-tissue defects at similar exposures. Do not withhold it, as cyanide poisoning is life-threatening.
- Allaitement
- Unknown Vitamin B12 injections at usual doses: B12 is a normal milk component; compatible. Cyanokit: present in milk; US label: do not breastfeed during treatment, and no data on when to restart.
Effets indésirables signalés
- Headache
- Nausea
- Increased blood pressure
- Erythema
- Chromaturia
- Decrease in lymphocytes
Précautions particulières
- Substantial increases in blood pressure may occur following therapy; monitor blood pressure during treatment
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Hydroxocobalamin used for?
Hydroxocobalamin is a medicine in the class miscellaneous. It is used for B12 deficiency, Cyanide poisoning.
What side effects have been reported with Hydroxocobalamin?
Headache, Nausea, Increased blood pressure, Erythema, Chromaturia, Decrease in lymphocytes.
Can Hydroxocobalamin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Vitamin B12 injections for deficiency are safe and needed in pregnancy. Cyanokit (5 g IV antidote for cyanide poisoning): human data insufficient; animal studies showed skeletal and soft-tissue defects at similar exposures. Do not withhold it, as cyanide poisoning is life-threatening. Breastfeeding: Unknown. Vitamin B12 injections at usual doses: B12 is a normal milk component; compatible. Cyanokit: present in milk; US label: do not breastfeed during treatment, and no data on when to restart.
What does Hydroxocobalamin interact with?
MediHelp does not list a checked interaction for Hydroxocobalamin yet. Always tell your pharmacist about every medicine you take.
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