Référentiel des médicaments
Niacin
Niacin is a medicine in the class cardiovascular. It is used for dietary supplement.
- Classe médicamenteuse: Cardiovascular
- Indications: dietary supplement
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Formes courantes
- comprimé
- Dosages courants
- 500 mg
- Interactions connues
- 47 (Modérée: 43 · Mineure: 4)
- Noms commerciaux
- 3
- Pays et marchés
- 2
Indications
Mécanisme d'action
Component of two coenzymes necessary for lipid metabolism, tissue respiration, glycogenolysis, inhibition of very low-density lipoprotein (VLDL) synthesis May increaase chylomicron triglyceride removal from plasma
Posologie adulte habituelle (résumé de la notice)
Nutritional Supplementation: Males: ≥19 years: 16 mg/day Females: ≥19 years: 14 mg/day Pregnant women: 18 mg/day Breastfeeding: 17 mg/day
Mode de prise habituel
Statins are taken by mouth once a day, long term, with blood tests to check the response and liver function.
Grossesse et allaitement
- Grossesse
- Unknown As a vitamin (B3) at normal doses: needed and safe in pregnancy. High-dose niacin for cholesterol: no human or animal data; US label: stop when pregnancy is recognised (for very high triglycerides, weigh risks and benefits).
- Allaitement
- Unsafe Vitamin doses: niacin is a normal part of milk; compatible. High-dose niacin for cholesterol: amounts in milk rise with the dose; US label: do not breastfeed during treatment because of possible serious infant effects, including liver toxicity.
Effets indésirables signalés
- Headache
- Diarrhea
- Pruritus
- Arrhythmias
- Reversible increase in serum aminotransferase
Précautions particulières
- Hepatotoxicity reported
- Use with caution in patients with history of liver disease, gout or gouty diathesis, diabetes mellitus, gallbladder disease, cardiovascular disease,
- Use with caution if patients are taking anticoagulants or HMG-CoA reductase inhibitors or if symptoms of myopathy occur (monitor creatine phosphokinase)
Unexplained muscle pain, tenderness or weakness while taking a statin should be reported promptly. Statins are not used in pregnancy, and some other medicines raise their levels and risk.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (47)
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
- Empagliflozin-metformin + Niacin Moderate
- Fluvastatin + Niacin Moderate
- Glipizide-metformin + Niacin Moderate
- Glyburide-metformin + Niacin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Autres médicaments de cette classe
Questions fréquentes
What is Niacin used for?
Niacin is a medicine in the class cardiovascular. It is used for Dietary supplement, Hyperlipidemia, Nutritional supplement.
What side effects have been reported with Niacin?
Headache, Diarrhea, Pruritus, Arrhythmias, Reversible increase in serum aminotransferase.
Can Niacin be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. As a vitamin (B3) at normal doses: needed and safe in pregnancy. High-dose niacin for cholesterol: no human or animal data; US label: stop when pregnancy is recognised (for very high triglycerides, weigh risks and benefits). Breastfeeding: Unsafe. Vitamin doses: niacin is a normal part of milk; compatible. High-dose niacin for cholesterol: amounts in milk rise with the dose; US label: do not breastfeed during treatment because of possible serious infant effects, including liver toxicity.
What does Niacin interact with?
MediHelp lists 47 known interactions for Niacin. Moderate: 43 · Minor: 4. The most serious include Alogliptin-metformin, Atorvastatin, Canagliflozin-metformin.
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