Référentiel des médicaments
Olsalazine
Olsalazine is a medicine in the class gastrointestinal tract. It is used for ulcerative colitis.
- Classe médicamenteuse: Gastrointestinal Tract
- Indications: ulcerative colitis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Gastrointestinal Tract
- Formes courantes
- gélule
- Dosages courants
- 250 mg
- Interactions connues
- 1 (Mineure: 1)
- Noms commerciaux
- 3
- Pays et marchés
- 3
Indications
Mécanisme d'action
Converted to 5-aminosalicylic acid (mesalamine) by gastrointestinal flora which is thought to be the therapeutically active component; works topically rather than systemically.
Posologie adulte habituelle (résumé de la notice)
Ulcerative Colitis Maintenance: 1g PO qDay in 2 divided doses, Take with food.
Grossesse et allaitement
- Grossesse
- Safe It releases mesalamine (5-ASA); meta-analyses and cohort studies of mesalamine show no reliable link with birth defects or miscarriage. Rats had developmental effects at 5 to 20 times the human dose. Active ulcerative colitis itself raises pregnancy risks, so continue when needed.
- Allaitement
- Safe Little olsalazine passes into milk, but mesalamine metabolites do (mesalamine relative infant dose 0.1% or less). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea. US label: weigh benefits.
Effets indésirables signalés
- Headache
- Diarrhea
- Abdominal pain
- Nausea/vomiting
Contre-indications
- Patients with known or suspected hypersensitivity to salicylates, aminosalicylates or their metabolites, or excipients
Précautions particulières
- Patients with pre-existing skin conditions such as atopic dermatitis and atopic eczema have reported more severe photosensitivity reactions when receiving therapy.
- Cases of nephrolithiasis have been reported with use of mesalamine; active moiety in drug, including stones with 100% mesalamine content.
- advise patients to avoid sun exposure, wear protective clothing, and use a broad-spectrum sunscreen when outdoors
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (1)
- Olsalazine + Warfarin Minor
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Paediatric dosing
- Pharmacokinetics
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Olsalazine used for?
Olsalazine is a medicine in the class gastrointestinal tract. It is used for Ulcerative colitis.
What side effects have been reported with Olsalazine?
Headache, Diarrhea, Abdominal pain, Nausea/vomiting.
Can Olsalazine be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. It releases mesalamine (5-ASA); meta-analyses and cohort studies of mesalamine show no reliable link with birth defects or miscarriage. Rats had developmental effects at 5 to 20 times the human dose. Active ulcerative colitis itself raises pregnancy risks, so continue when needed. Breastfeeding: Safe. Little olsalazine passes into milk, but mesalamine metabolites do (mesalamine relative infant dose 0.1% or less). A few infants had diarrhoea. LactMed: not a reason to stop breastfeeding; watch the infant for diarrhoea. US label: weigh benefits.
What does Olsalazine interact with?
MediHelp lists 1 known interactions for Olsalazine. Minor: 1. The most serious include Warfarin.
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