Référentiel des médicaments
Pegfilgrastim
Pegfilgrastim is a medicine in the class miscellaneous. It is used for neutropenia.
- Classe médicamenteuse: Miscellaneous
- Indications: neutropenia
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Miscellaneous
- Code ATC
- L03AA13
- Formes courantes
- injection
- Dosages courants
- 6 mg/.6 ml, 6 mg, 6 mg/0.6 ml
- Interactions connues
- 1 (Modérée: 1)
- Noms commerciaux
- 25
- Pays et marchés
- 3
Indications
Mécanisme d'action
Recombinant PEG-conjugated human G-CSF; acts on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end-cell functional activation
Posologie adulte habituelle (résumé de la notice)
Prevention of Chemotherapy-induced Neutropenia: 6 mg SC once per chemotherapy cycle
Grossesse et allaitement
- Grossesse
- Unknown Limited pegfilgrastim data; filgrastim studies show no link to birth defects or miscarriage. No harm in rats at 10 times the dose; rabbit fetal loss only with maternal toxicity. EU label: not recommended in pregnancy or without contraception. Filgrastim has more data; use only if clearly needed.
- Allaitement
- Safe No milk data for pegfilgrastim. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. LactMed (filgrastim record, covers pegfilgrastim): G-CSFs pass poorly into milk and are not absorbed by the infant's gut, so harm is unlikely; some advise pausing feeds for 3 days.
Effets indésirables signalés
- Bone pain
- Pain in extremity
- Leukocytosis
- Sickle cell crisis
Précautions particulières
- Severe and sometimes fatal sickle cell crises can occur in patients with sickle cell disorders; discontinue therapy if sickle cell crisis occurs
- ARDS reported; evaluate symptoms, including fever, pulmonary infiltrates, or respiratory distress; discontinue if ARDS occurs
- Rare cases of splenic rupture may occur; evaluate if patient experiences left upper abdominal and/or shoulder tip pain
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (1)
- Ifosfamide + Pegfilgrastim Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Pegfilgrastim used for?
Pegfilgrastim is a medicine in the class miscellaneous. It is used for Neutropenia, Radiation syndrome.
What side effects have been reported with Pegfilgrastim?
Bone pain, Pain in extremity, Leukocytosis, Sickle cell crisis.
Can Pegfilgrastim be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Limited pegfilgrastim data; filgrastim studies show no link to birth defects or miscarriage. No harm in rats at 10 times the dose; rabbit fetal loss only with maternal toxicity. EU label: not recommended in pregnancy or without contraception. Filgrastim has more data; use only if clearly needed. Breastfeeding: Safe. No milk data for pegfilgrastim. EU label: risk cannot be excluded; decide whether to stop breastfeeding or the drug. LactMed (filgrastim record, covers pegfilgrastim): G-CSFs pass poorly into milk and are not absorbed by the infant's gut, so harm is unlikely; some advise pausing feeds for 3 days.
What does Pegfilgrastim interact with?
MediHelp lists 1 known interactions for Pegfilgrastim. Moderate: 1. The most serious include Ifosfamide.
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