Référentiel des médicaments
Pyrilamine
Pyrilamine is a medicine in the class respiratory. It is used for allergic rhinitis.
- Classe médicamenteuse: Respiratory
- Indications: allergic rhinitis
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Respiratory
- Formes courantes
- solution
- Dosages courants
- 12.5 mg/15 ml
- Interactions connues
- 8 (Modérée: 2 · Mineure: 6)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Pyrilamine (mepyramine) is a first-generation ethylenediamine-class antihistamine that acts as an inverse agonist (competitive antagonist) at histamine H1 receptors. It blocks histamine-mediated vasodilation, increased capillary permeability and sensory nerve stimulation, which reduces sneezing, rhinorrhoea and itching.
Grossesse et allaitement
- Grossesse
- Unknown An older sedating antihistamine (mepyramine), often in cold or period-pain combinations. Human data are limited, with no clear link to birth defects. Loratadine, cetirizine or chlorphenamine are preferred; avoid decongestant combinations early in pregnancy.
- Allaitement
- Safe Small, occasional doses are not expected to harm the infant (LactMed: probably acceptable). Larger or prolonged doses may sedate the infant or lower milk supply, especially with a decongestant such as pseudoephedrine or before lactation is established. Non-sedating antihistamines are preferred.
Effets indésirables signalés
- Marked drowsiness
- Excitability, especially in children
Précautions particulières
- Ask a doctor before use if the child has a breathing problem such as emphysema or chronic bronchitis.
- Ask a doctor before use if the child has glaucoma.
- Marked drowsiness may occur; excitability may occur, especially in children.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (8)
- Fentanyl + Pyrilamine Moderate
- Levetiracetam + Pyrilamine Moderate
- Amisulpride + Pyrilamine Minor
- Asenapine + Pyrilamine Minor
- Brexpiprazole + Pyrilamine Minor
- Brimonidine + Pyrilamine Minor
- Brivaracetam + Pyrilamine Minor
- Cariprazine + Pyrilamine Minor
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- Paediatric dosing
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Questions fréquentes
What is Pyrilamine used for?
Pyrilamine is a medicine in the class respiratory. It is used for Allergic rhinitis, Hay fever.
What side effects have been reported with Pyrilamine?
Marked drowsiness, Excitability, especially in children.
Can Pyrilamine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. An older sedating antihistamine (mepyramine), often in cold or period-pain combinations. Human data are limited, with no clear link to birth defects. Loratadine, cetirizine or chlorphenamine are preferred; avoid decongestant combinations early in pregnancy. Breastfeeding: Safe. Small, occasional doses are not expected to harm the infant (LactMed: probably acceptable). Larger or prolonged doses may sedate the infant or lower milk supply, especially with a decongestant such as pseudoephedrine or before lactation is established. Non-sedating antihistamines are preferred.
What does Pyrilamine interact with?
MediHelp lists 8 known interactions for Pyrilamine. Moderate: 2 · Minor: 6. The most serious include Fentanyl, Levetiracetam, Amisulpride.
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