Interactions médicamenteuses
Abatacept + Dengue vaccine
Gravité: Majeure
Abatacept and Dengue vaccine: major interaction.
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Résumé
Dengue vaccine (Dengvaxia) is a live attenuated vaccine, so it carries a risk of vaccine-related infection in immunosuppressed people. Abatacept may also reduce the immune response to the vaccine.
Ce que signifie cette interaction, en termes simples
Abatacept and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Immunosuppression impairs control of live attenuated virus replication and reduces vaccine immunogenicity.
Conduite à tenir
Avoid live vaccines during abatacept therapy and for several weeks after the last dose, which is roughly 3 months. Consider vaccination before starting treatment.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Abatacept
- Abatacept + Adalimumab Majeure
- Abatacept + Adenovirus types 4 and 7 live Majeure
- Abatacept + Anakinra Majeure
- Abatacept + Baricitinib Majeure
- Abatacept + Belatacept Majeure
- Abatacept + Certolizumab pegol Majeure
Questions fréquentes
Can I take Abatacept with Dengue vaccine?
MediHelp rates the interaction as major. Abatacept and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine (Dengvaxia) is a live attenuated vaccine, so it carries a risk of vaccine-related infection in immunosuppressed people. Abatacept may also reduce the immune response to the vaccine.
How serious is the interaction between Abatacept and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during abatacept therapy and for several weeks after the last dose, which is roughly 3 months. Consider vaccination before starting treatment.
What other medicines interact with Abatacept?
MediHelp also lists interactions of Abatacept with, for example, Adalimumab, Adenovirus types 4 and 7 live, Anakinra. The full list is on the Abatacept page.
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