Interactions médicamenteuses
Acemetacin + Amiloride
Gravité: Majeure
Acemetacin and Amiloride: major interaction.
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Résumé
Acemetacin, an NSAID, can reduce renal prostaglandins and impair potassium excretion, adding to amiloride's potassium retention. It may also reduce the diuretic and antihypertensive effects and raise the risk of acute kidney injury.
Ce que signifie cette interaction, en termes simples
Acemetacin and Amiloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
NSAID-induced suppression of renin-aldosterone and renal prostaglandins reduces potassium and sodium excretion, combined with amiloride's ENaC blockade.
Conduite à tenir
Avoid the combination where possible, especially in CKD or the elderly. If needed, monitor potassium, creatinine and blood pressure closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amiloride
- Amiloride + Eplerenone Contre-indiquée
- Amiloride + Spironolactone Contre-indiquée
- Amiloride + Triamterene Contre-indiquée
- Aceclofenac + Amiloride Majeure
- Amiloride + Amlodipine-benazepril Majeure
- Amiloride + Amlodipine-hydrochlorothiazide-valsartan Majeure
Questions fréquentes
Can I take Acemetacin with Amiloride?
MediHelp rates the interaction as major. Acemetacin and Amiloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acemetacin, an NSAID, can reduce renal prostaglandins and impair potassium excretion, adding to amiloride's potassium retention. It may also reduce the diuretic and antihypertensive effects and raise the risk of acute kidney injury.
How serious is the interaction between Acemetacin and Amiloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, especially in CKD or the elderly. If needed, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Amiloride?
MediHelp also lists interactions of Amiloride with, for example, Eplerenone, Spironolactone, Triamterene. The full list is on the Amiloride page.
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