Interactions médicamenteuses
Acetylsalicylic acid + Sodium bicarbonate
Gravité: Modérée
Acetylsalicylic acid and Sodium bicarbonate: moderate interaction.
Dernière mise à jour
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Résumé
Sodium bicarbonate alkalinizes urine, which ionizes salicylate and increases its renal excretion, lowering salicylate levels. This effect is used therapeutically in salicylate poisoning but can reduce the effect of anti-inflammatory aspirin doses. Antacid doses may also alter absorption slightly.
Ce que signifie cette interaction, en termes simples
Acetylsalicylic acid and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Acetylsalicylic acid belongs to Musculoskeletal; Sodium bicarbonate belongs to Gastrointestinal Tract.
Pourquoi elle survient
Urinary alkalinization increases ionization of salicylic acid, reducing renal tubular reabsorption and increasing clearance.
Conduite à tenir
With chronic high-dose aspirin therapy, monitor clinical response or salicylate levels when starting or stopping regular bicarbonate. Consider non-alkalinizing alternatives for antacid use.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Acetylsalicylic acid
- Acetylsalicylic acid + Ketorolac Contre-indiquée
- Acetylsalicylic acid + Ketorolac intranasal Contre-indiquée
- Abciximab + Acetylsalicylic acid Majeure
- Acemetacin + Acetylsalicylic acid Majeure
- Acetazolamide + Acetylsalicylic acid Majeure
- Acetylsalicylic acid + Alteplase Majeure
Autres interactions de Sodium bicarbonate
- Alendronate + Sodium bicarbonate Modérée
- Amantadine + Sodium bicarbonate Modérée
- Carbonyl iron + Sodium bicarbonate Modérée
- Cefditoren + Sodium bicarbonate Modérée
- Cefpodoxime + Sodium bicarbonate Modérée
- Cefuroxime + Sodium bicarbonate Modérée
Questions fréquentes
Can I take Acetylsalicylic acid with Sodium bicarbonate?
MediHelp rates the interaction as moderate. Acetylsalicylic acid and Sodium bicarbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium bicarbonate alkalinizes urine, which ionizes salicylate and increases its renal excretion, lowering salicylate levels. This effect is used therapeutically in salicylate poisoning but can reduce the effect of anti-inflammatory aspirin doses. Antacid doses may also alter absorption slightly.
How serious is the interaction between Acetylsalicylic acid and Sodium bicarbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With chronic high-dose aspirin therapy, monitor clinical response or salicylate levels when starting or stopping regular bicarbonate. Consider non-alkalinizing alternatives for antacid use.
What other medicines interact with Acetylsalicylic acid?
MediHelp also lists interactions of Acetylsalicylic acid with, for example, Ketorolac, Ketorolac intranasal, Abciximab. The full list is on the Acetylsalicylic acid page.
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