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Interactions médicamenteuses

Acitretin + Palovarotene

Gravité: Contre-indiquée

Acitretin and Palovarotene: contraindicated interaction.

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Résumé

Both are retinoids, and using them together adds to total retinoid exposure. This increases the risk of hypervitaminosis A toxicity, including skin, bone, liver and lipid effects, and additive teratogenicity.

Ce que signifie cette interaction, en termes simples

Acitretin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Acitretin belongs to Miscellaneous; Palovarotene belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive retinoid pharmacodynamic effects leading to hypervitaminosis A.

Conduite à tenir

Do not combine; avoid other oral retinoids during palovarotene therapy. Choose a non-retinoid alternative.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Acitretin with Palovarotene?

MediHelp rates the interaction as contraindicated. Acitretin and Palovarotene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are retinoids, and using them together adds to total retinoid exposure. This increases the risk of hypervitaminosis A toxicity, including skin, bone, liver and lipid effects, and additive teratogenicity.

How serious is the interaction between Acitretin and Palovarotene?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid other oral retinoids during palovarotene therapy. Choose a non-retinoid alternative.

What other medicines interact with Acitretin?

MediHelp also lists interactions of Acitretin with, for example, Demeclocycline, Doxycycline, Ethanol. The full list is on the Acitretin page.

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