Interactions médicamenteuses
Activated charcoal + Methotrexate
Gravité: Modérée
Activated charcoal and Methotrexate: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Activated charcoal binds methotrexate in the gut and can interrupt its enterohepatic recirculation, lowering its levels. This reduces the effect of therapeutic doses but is used deliberately in overdose.
Ce que signifie cette interaction, en termes simples
Activated charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Activated charcoal belongs to Gastrointestinal Tract; Methotrexate belongs to Oncology.
Pourquoi elle survient
Adsorption of methotrexate in the gastrointestinal tract reduces absorption and enterohepatic reabsorption.
Conduite à tenir
Separate charcoal from oral methotrexate doses unless it is being given for overdose. In overdose, consider repeated charcoal alongside leucovorin and supportive care.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Activated charcoal et Methotrexate, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Methotrexate
- Acitretin + Methotrexate Contre-indiquée
- Adenovirus types 4 and 7 live + Methotrexate Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contre-indiquée
- Ketorolac + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine live + Methotrexate Contre-indiquée
- Measles mumps and rubella vaccine + Methotrexate Contre-indiquée
Autres interactions de Activated charcoal
Questions fréquentes
Can I take Activated charcoal with Methotrexate?
MediHelp rates the interaction as moderate. Activated charcoal and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Activated charcoal binds methotrexate in the gut and can interrupt its enterohepatic recirculation, lowering its levels. This reduces the effect of therapeutic doses but is used deliberately in overdose.
How serious is the interaction between Activated charcoal and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate charcoal from oral methotrexate doses unless it is being given for overdose. In overdose, consider repeated charcoal alongside leucovorin and supportive care.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
