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Interactions médicamenteuses

Adefovir + Emtricitabine

Gravité: Modérée

Adefovir and Emtricitabine: moderate interaction.

Dernière mise à jour

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Résumé

Both drugs are eliminated by the kidneys through filtration and active tubular secretion. Competition for secretion may raise concentrations of either drug, and adefovir's nephrotoxicity may further impair emtricitabine clearance.

Ce que signifie cette interaction, en termes simples

Adefovir and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Adefovir belongs to Anti Virals; Emtricitabine belongs to Anti Virals.

Niveau de preuve: Low

Pourquoi elle survient

Competition for renal tubular secretion and additive effects on renal function.

Conduite à tenir

Monitor renal function regularly and adjust the dosing interval of emtricitabine if creatinine clearance falls.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Adefovir with Emtricitabine?

MediHelp rates the interaction as moderate. Adefovir and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated by the kidneys through filtration and active tubular secretion. Competition for secretion may raise concentrations of either drug, and adefovir's nephrotoxicity may further impair emtricitabine clearance.

How serious is the interaction between Adefovir and Emtricitabine?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function regularly and adjust the dosing interval of emtricitabine if creatinine clearance falls.

What other medicines interact with Adefovir?

MediHelp also lists interactions of Adefovir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Amikacin, Amphotericin b. The full list is on the Adefovir page.

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