Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Adefovir + Streptomycin

Gravité: Majeure

Adefovir and Streptomycin: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Adefovir can cause dose-related proximal tubular nephrotoxicity, and streptomycin is also nephrotoxic. Concurrent use increases the risk of kidney injury and may raise aminoglycoside exposure and ototoxicity.

Ce que signifie cette interaction, en termes simples

Adefovir and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Adefovir belongs to Anti Virals; Streptomycin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive nephrotoxicity affecting the proximal tubule, with reduced clearance of renally eliminated drugs.

Conduite à tenir

Avoid concurrent use when possible. If necessary, monitor serum creatinine and phosphate regularly, adjust adefovir dosing interval to renal function, and monitor streptomycin levels and hearing.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Adefovir et Streptomycin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Adefovir with Streptomycin?

MediHelp rates the interaction as major. Adefovir and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adefovir can cause dose-related proximal tubular nephrotoxicity, and streptomycin is also nephrotoxic. Concurrent use increases the risk of kidney injury and may raise aminoglycoside exposure and ototoxicity.

How serious is the interaction between Adefovir and Streptomycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when possible. If necessary, monitor serum creatinine and phosphate regularly, adjust adefovir dosing interval to renal function, and monitor streptomycin levels and hearing.

What other medicines interact with Streptomycin?

MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Amikacin, Amphotericin b deoxycholate. The full list is on the Streptomycin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter