Interactions médicamenteuses
Adenovirus types 4 and 7 live + Dacarbazine
Gravité: Majeure
Adenovirus types 4 and 7 live and Dacarbazine: major interaction.
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Résumé
Dacarbazine causes immunosuppression, so a live oral adenovirus vaccine may fail to produce protective immunity and the vaccine virus may replicate and cause disease. Live vaccines are generally avoided in patients on myelosuppressive chemotherapy.
Ce que signifie cette interaction, en termes simples
Adenovirus types 4 and 7 live and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Chemotherapy-induced immunosuppression impairs vaccine response and permits uncontrolled replication of live attenuated virus.
Conduite à tenir
Avoid live vaccines during chemotherapy and for at least 3 months after stopping. Use alternatives or defer vaccination until immune recovery.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dacarbazine
- Axicabtagene ciloleucel + Dacarbazine Majeure
- Belatacept + Dacarbazine Majeure
- Brexucabtagene autoleucel + Dacarbazine Majeure
- Carmustine + Dacarbazine Majeure
- Ciltacabtagene autoleucel + Dacarbazine Majeure
- Dacarbazine + Dengue vaccine Majeure
Questions fréquentes
Can I take Adenovirus types 4 and 7 live with Dacarbazine?
MediHelp rates the interaction as major. Adenovirus types 4 and 7 live and Dacarbazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacarbazine causes immunosuppression, so a live oral adenovirus vaccine may fail to produce protective immunity and the vaccine virus may replicate and cause disease. Live vaccines are generally avoided in patients on myelosuppressive chemotherapy.
How serious is the interaction between Adenovirus types 4 and 7 live and Dacarbazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy and for at least 3 months after stopping. Use alternatives or defer vaccination until immune recovery.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Axicabtagene ciloleucel, Belatacept, Brexucabtagene autoleucel. The full list is on the Dacarbazine page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
