Interactions médicamenteuses
Aldesleukin + Budesonide
Gravité: Majeure
Aldesleukin and Budesonide: major interaction.
Dernière mise à jour
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Résumé
Corticosteroids can blunt the immune activation that underlies the antitumor activity of aldesleukin, so efficacy may be reduced. Systemic budesonide exposure is lower than that of other systemic steroids but remains relevant with oral formulations.
Ce que signifie cette interaction, en termes simples
Aldesleukin and Budesonide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Aldesleukin belongs to Oncology; Budesonide belongs to Respiratory.
Pourquoi elle survient
Pharmacodynamic antagonism: corticosteroid immunosuppression opposes interleukin-2-mediated lymphocyte activation.
Conduite à tenir
Avoid systemic corticosteroids, including oral budesonide, during aldesleukin therapy unless needed to treat life-threatening toxicity. Inhaled or topical use carries less concern.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Budesonide
- Atazanavir + Budesonide Majeure
- Bcg vaccine live + Budesonide Majeure
- Budesonide + Ceritinib Majeure
- Budesonide + Clarithromycin Majeure
- Budesonide + Cobicistat Majeure
- Budesonide + Darunavir Majeure
Autres interactions de Aldesleukin
Questions fréquentes
Can I take Aldesleukin with Budesonide?
MediHelp rates the interaction as major. Aldesleukin and Budesonide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Corticosteroids can blunt the immune activation that underlies the antitumor activity of aldesleukin, so efficacy may be reduced. Systemic budesonide exposure is lower than that of other systemic steroids but remains relevant with oral formulations.
How serious is the interaction between Aldesleukin and Budesonide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic corticosteroids, including oral budesonide, during aldesleukin therapy unless needed to treat life-threatening toxicity. Inhaled or topical use carries less concern.
What other medicines interact with Budesonide?
MediHelp also lists interactions of Budesonide with, for example, Atazanavir, Bcg vaccine live, Ceritinib. The full list is on the Budesonide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
