Interactions médicamenteuses
Aldesleukin + Phenoxybenzamine
Gravité: Modérée
Aldesleukin and Phenoxybenzamine: moderate interaction.
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Résumé
Phenoxybenzamine is a long-acting alpha-blocker that causes vasodilation and orthostatic hypotension. With aldesleukin, which causes hypotension from capillary leak, blood pressure may fall severely.
Ce que signifie cette interaction, en termes simples
Aldesleukin and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Additive pharmacodynamic hypotension from irreversible alpha-adrenergic blockade and aldesleukin-induced vasodilation.
Conduite à tenir
Monitor blood pressure closely during aldesleukin therapy and reduce or hold phenoxybenzamine if hypotension develops. Because its effect is long-lasting, plan dose changes ahead of treatment cycles.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Aldesleukin
Questions fréquentes
Can I take Aldesleukin with Phenoxybenzamine?
MediHelp rates the interaction as moderate. Aldesleukin and Phenoxybenzamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenoxybenzamine is a long-acting alpha-blocker that causes vasodilation and orthostatic hypotension. With aldesleukin, which causes hypotension from capillary leak, blood pressure may fall severely.
How serious is the interaction between Aldesleukin and Phenoxybenzamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure closely during aldesleukin therapy and reduce or hold phenoxybenzamine if hypotension develops. Because its effect is long-lasting, plan dose changes ahead of treatment cycles.
What other medicines interact with Aldesleukin?
MediHelp also lists interactions of Aldesleukin with, for example, Alfuzosin, Amifostine, Amlodipine-benazepril. The full list is on the Aldesleukin page.
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