Interactions médicamenteuses
Alfentanil + Phenelzine
Gravité: Majeure
Alfentanil and Phenelzine: major interaction.
Dernière mise à jour
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Résumé
Opioids given with MAOIs can cause serotonin toxicity or exaggerated opioid effects including respiratory depression, hypotension and coma. Alfentanil is generally avoided in patients on phenelzine.
Ce que signifie cette interaction, en termes simples
Alfentanil and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Probable additive CNS depression and serotonergic effects; mechanism not fully established.
Conduite à tenir
Avoid within 14 days of MAOI therapy and choose an alternative agent. If essential, use small titrated doses with continuous monitoring of respiration and hemodynamics.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Phenelzine
- 5-HTP + Phenelzine Contre-indiquée
- Amitriptyline + Phenelzine Contre-indiquée
- Amoxapine + Phenelzine Contre-indiquée
- Atomoxetine + Phenelzine Contre-indiquée
- Benzphetamine + Phenelzine Contre-indiquée
- Brimonidine + Phenelzine Contre-indiquée
Questions fréquentes
Can I take Alfentanil with Phenelzine?
MediHelp rates the interaction as major. Alfentanil and Phenelzine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids given with MAOIs can cause serotonin toxicity or exaggerated opioid effects including respiratory depression, hypotension and coma. Alfentanil is generally avoided in patients on phenelzine.
How serious is the interaction between Alfentanil and Phenelzine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid within 14 days of MAOI therapy and choose an alternative agent. If essential, use small titrated doses with continuous monitoring of respiration and hemodynamics.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
