Interactions médicamenteuses
Alogliptin-metformin + Ethanol
Gravité: Majeure
Alogliptin-metformin and Ethanol: major interaction.
Dernière mise à jour
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Résumé
Alcohol impairs hepatic lactate clearance and may potentiate metformin-associated lactic acidosis, and excessive intake disturbs glucose control. The risk is mainly related to the metformin component.
Ce que signifie cette interaction, en termes simples
Alogliptin-metformin and Ethanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Ethanol suppresses hepatic lactate metabolism and gluconeogenesis, adding to the lactate-raising effect of metformin.
Conduite à tenir
Advise patients to avoid excessive or binge drinking. Consider stopping metformin in chronic alcohol misuse and monitor glucose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Alogliptin-metformin
Questions fréquentes
Can I take Alogliptin-metformin with Ethanol?
MediHelp rates the interaction as major. Alogliptin-metformin and Ethanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Alcohol impairs hepatic lactate clearance and may potentiate metformin-associated lactic acidosis, and excessive intake disturbs glucose control. The risk is mainly related to the metformin component.
How serious is the interaction between Alogliptin-metformin and Ethanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid excessive or binge drinking. Consider stopping metformin in chronic alcohol misuse and monitor glucose.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
