Interactions médicamenteuses
Amphotericin b + Polymyxin b
Gravité: Majeure
Amphotericin b and Polymyxin b: major interaction.
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Résumé
Both drugs can injure the kidneys, and polymyxin B also has neurotoxic effects. Combined use increases the risk of acute kidney injury and may raise polymyxin exposure.
Ce que signifie cette interaction, en termes simples
Amphotericin b and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Polymyxin b belongs to Anti Bacterial.
Pourquoi elle survient
Additive nephrotoxicity through direct tubular cell injury.
Conduite à tenir
Avoid concomitant use if possible. If both are essential, monitor renal function and electrolytes frequently and keep the patient well hydrated.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Amphotericin b
- Amphotericin b + Cidofovir Contre-indiquée
- Adefovir + Amphotericin b Majeure
- Amikacin + Amphotericin b Majeure
- Amphotericin b + Arsenic trioxide Majeure
- Amphotericin b + Capreomycin Majeure
- Amphotericin b + Cephaloridine Majeure
Autres interactions de Polymyxin b
- Cidofovir + Polymyxin b Contre-indiquée
- Colistin + Polymyxin b Contre-indiquée
- Acyclovir + Polymyxin b Majeure
- Adefovir + Polymyxin b Majeure
- Amikacin + Polymyxin b Majeure
- Atracurium + Polymyxin b Majeure
Questions fréquentes
Can I take Amphotericin b with Polymyxin b?
MediHelp rates the interaction as major. Amphotericin b and Polymyxin b can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidneys, and polymyxin B also has neurotoxic effects. Combined use increases the risk of acute kidney injury and may raise polymyxin exposure.
How serious is the interaction between Amphotericin b and Polymyxin b?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use if possible. If both are essential, monitor renal function and electrolytes frequently and keep the patient well hydrated.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
