Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Amphotericin b + Tobramycin

Gravité: Majeure

Amphotericin b and Tobramycin: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Both drugs are nephrotoxic, and tobramycin is also ototoxic and vestibulotoxic. Combined use raises the risk of acute kidney injury, which in turn increases aminoglycoside accumulation and the risk of permanent hearing or balance damage.

Ce que signifie cette interaction, en termes simples

Amphotericin b and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amphotericin b belongs to Anti Fungals; Tobramycin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Additive nephrotoxicity from renal tubular injury, with reduced aminoglycoside clearance amplifying ototoxicity.

Conduite à tenir

Avoid the combination if an alternative exists. If it is necessary, monitor serum creatinine, electrolytes and tobramycin levels frequently, ensure hydration, and consider a lipid-based amphotericin formulation.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Amphotericin b et Tobramycin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.

Questions fréquentes

Can I take Amphotericin b with Tobramycin?

MediHelp rates the interaction as major. Amphotericin b and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and tobramycin is also ototoxic and vestibulotoxic. Combined use raises the risk of acute kidney injury, which in turn increases aminoglycoside accumulation and the risk of permanent hearing or balance damage.

How serious is the interaction between Amphotericin b and Tobramycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor serum creatinine, electrolytes and tobramycin levels frequently, ensure hydration, and consider a lipid-based amphotericin formulation.

What other medicines interact with Amphotericin b?

MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter