Interactions médicamenteuses
Armodafinil + Cyclosporine
Gravité: Majeure
Armodafinil and Cyclosporine: major interaction.
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Résumé
Armodafinil may lower cyclosporine concentrations through enzyme induction. Reduced levels of this narrow-therapeutic-index drug could risk graft rejection.
Ce que signifie cette interaction, en termes simples
Armodafinil and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Armodafinil induces CYP3A4, which increases the metabolism of cyclosporine.
Conduite à tenir
Measure cyclosporine trough levels after armodafinil is started or stopped and adjust the dose accordingly. Watch for signs of rejection.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Armodafinil
- Armodafinil + Avapritinib Majeure
- Armodafinil + Elacestrant Majeure
- Armodafinil + Elbasvir / grazoprevir Majeure
- Armodafinil + Entrectinib Majeure
- Armodafinil + Ethinylestradiol Majeure
- Armodafinil + Etonogestrel Majeure
Questions fréquentes
Can I take Armodafinil with Cyclosporine?
MediHelp rates the interaction as major. Armodafinil and Cyclosporine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Armodafinil may lower cyclosporine concentrations through enzyme induction. Reduced levels of this narrow-therapeutic-index drug could risk graft rejection.
How serious is the interaction between Armodafinil and Cyclosporine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure cyclosporine trough levels after armodafinil is started or stopped and adjust the dose accordingly. Watch for signs of rejection.
What other medicines interact with Armodafinil?
MediHelp also lists interactions of Armodafinil with, for example, Avapritinib, Elacestrant, Elbasvir / grazoprevir. The full list is on the Armodafinil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
