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Interactions médicamenteuses

Arsenic trioxide + Hydroxychloroquine

Gravité: Contre-indiquée

Arsenic trioxide and Hydroxychloroquine: contraindicated interaction.

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Résumé

Arsenic trioxide causes marked QT prolongation and torsades de pointes, and adding hydroxychloroquine further increases this risk. The combination can lead to life-threatening arrhythmias.

Ce que signifie cette interaction, en termes simples

Arsenic trioxide and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Arsenic trioxide belongs to Oncology; Hydroxychloroquine belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation through effects on cardiac ion channels and repolarization.

Conduite à tenir

Avoid concurrent use and choose an alternative to hydroxychloroquine during arsenic trioxide therapy. If it cannot be avoided, require continuous ECG surveillance with strict correction of potassium and magnesium.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Arsenic trioxide with Hydroxychloroquine?

MediHelp rates the interaction as contraindicated. Arsenic trioxide and Hydroxychloroquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and torsades de pointes, and adding hydroxychloroquine further increases this risk. The combination can lead to life-threatening arrhythmias.

How serious is the interaction between Arsenic trioxide and Hydroxychloroquine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative to hydroxychloroquine during arsenic trioxide therapy. If it cannot be avoided, require continuous ECG surveillance with strict correction of potassium and magnesium.

What other medicines interact with Hydroxychloroquine?

MediHelp also lists interactions of Hydroxychloroquine with, for example, Cisapride, Dronedarone, Pimozide. The full list is on the Hydroxychloroquine page.

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