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Interactions médicamenteuses

Arsenic trioxide + Pazopanib

Gravité: Majeure

Arsenic trioxide and Pazopanib: major interaction.

Dernière mise à jour

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Résumé

Both drugs prolong the QT interval, and arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes. Combined use increases the risk of serious ventricular arrhythmias.

Ce que signifie cette interaction, en termes simples

Arsenic trioxide and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Arsenic trioxide belongs to Oncology; Pazopanib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive prolongation of cardiac repolarization (QT interval) through pharmacodynamic effects.

Conduite à tenir

Avoid the combination if possible; otherwise obtain baseline and serial ECGs and keep potassium and magnesium within normal range. Stop or reduce therapy if QTc becomes markedly prolonged.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Arsenic trioxide with Pazopanib?

MediHelp rates the interaction as major. Arsenic trioxide and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, and arsenic trioxide carries a boxed warning for QT prolongation and torsades de pointes. Combined use increases the risk of serious ventricular arrhythmias.

How serious is the interaction between Arsenic trioxide and Pazopanib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise obtain baseline and serial ECGs and keep potassium and magnesium within normal range. Stop or reduce therapy if QTc becomes markedly prolonged.

What other medicines interact with Pazopanib?

MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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